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Mitochondria permeability transition versus necroptosis in oxalate-induced AKI

The collagen group showed significant WOMAC pain score improvement: -1.90 4.14 versus +0.61 3.97 for placebo (p=0.006)

Clinical and postmortem studies consistently demonstrate reduced BDNF expression and diminished neurogenic capacity in individuals with depression, while effective antidepressant treatments, including SSRIs, SNRIs, and electroconvulsive therapy, restore neurogenesis and promote neuronal maturation

This response is mediated by OS/nitrosative stress and inflammation, which could lead to cell death of enterocytes with capability to transport Ca 2+ across the cells and in the paracellular route